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Starting dose for children is 5 mg twice daily, 3-4 hours apart. May increase total daily dose by 5 mg per week until reach optimal level. Over 6 years, one or two additional doses may be given at 4-6 hour intervals. Use cautiously in patients with marked anxiety, motor tics or with family history of Tourette syndrome, or history of substance abuse. Increase total daily dose by 5 mg per week until reach optimal dose to maximum of 40 mg/day. The targeted clinical dose is approximately 1.2 mg/kg. It may be divided into a morning and an evening dose, particularly if need higher doses.